How To Obtain The Best Results
Take 3 NITROvit® capsules either 1 hour before or 1 hour after breakfast.
Alternatively take 2 capsules either 1 hour before or 1 hour after breakfast and a further 1 capsule 1 hour after lunch.
Do not consume more than 4 capsules in a 24-hour period. For best results take 2 days rest from NITROvit® per week on a 5 days on – 2 days off rotation. This allows the body time to reset and helps avoid tolerance build-up.
NOTE: Not intended for use by persons under the age of 18. Not for use by pregnant or lactating women.
Alpha GPC - 450 mg
Alpha GPC is a cholinergic nootropic derived from sunflower or soy lecithin. Although a small amount of Alpha GPC is present in the body, supplementation is recommended to improve memory, learning, and reverse the damage caused by age-related cognitive decline.
Alpha GPC Benefits: As a choline source, the primary function of Alpha GPC is to stimulate the production of acetylcholine. The brain is dependent on the neurotransmitter acetylcholine for efficient transmission of signals between neurons. Supplying the brain with the acetylcholine precursor is a surefire way to boost memory, mental clarity, learning, attention, and cognitive processing.
The nootropic Alpha GPC has proved itself equally good at aiding the development of cell membranes in the brain. The cerebral cortex (i.e.) the section of the brain that houses the gray matter or top layer of the neural tissues is the site where the majority of the information that the senses gather are processed. By helping cell membrane development in the cerebral cortex, the nootropic Alpha GPC positively influences touch, motor function, and intelligence.
To prevent age-related neurodegeneration it’s essential to preserve the health of the neuronal membrane. One of the functions of Alpha GPC is to promote neuronal cell health, thus preventing and sometimes reversing the symptoms of dementia and disorders such as Alzheimer’s and Parkinson's.
Cognitive Improvement in Alzheimer’s Dementia After Treatment with Alpha GPC
Alpha Lipoic Acid - 75 mg
The sulfur-containing fatty acid Alpha-Lipoic Acid has almost magic-like antioxidant properties. Its powers far exceed that of any other antioxidant supplement. Antioxidants are those vital compounds that defend the tissues and organs from the ravages of time. Alpha-Lipoic Acid, in its own right, is a potent antioxidant. In addition, it rejuvenates, revitalizes, and reactivates other antioxidants that have performed their functions and become a spent force.
Alpha-Lipoic Acid Benefits: The most significant function of ALA is to prevent a whole host of undesirable functions, chemical reactions to be more precise, from damaging the cells, tissues, and organs in the body; doing so the nootropic supplement prevents a wide range of chronic diseases.
As a nootropic, Alpha-Lipoic Acid counters the damages inflicted by oxidative stress. Its neuroprotective properties are the brain’s best defense against age-related cognitive decline. Studies show that by protecting the neurons and boosting neurotransmitter levels, ALA can treat forgetfulness, confusion; attention deficit, irritability, and other sever symptoms of cognitive decline. The supplement is also known to prevent and treat Alzheimer’s and similar disorders.
Another reason for neurodegeneration is the accumulation of heavy metals and toxic material in the cells. Alpha-Lipoic Acid reduces toxicity by increasing vitamin C levels, preventing glutathione loss, and flushing out heavy metals. Reducing toxicity and reactivating other antioxidants such as CoQ10 helps boost memory and increase cellular energy. ALA is also known to regulate blood glucose levels.
BioPerine® - 9 mg
BioPerine is the trademark name of Piperine – the active component found in black pepper that gives the spice its hot taste and the heat it generates in the body. For thousands of years, black pepper, in various forms, has been used in traditional medicine to treat ailments and improve overall health. This particular supplement – BioPerine – is primarily used to enhance the bioavailability of nutrients. Piperine is also believed to boost metabolism, treat depression, improve mental health, and reduce inflammation.
BioPerine Benefits: BioPerine is best known for its role in the absorption of nutrients from the stomach and small intestine. Its ability to increase the uptake of several nutrients makes BioPerine one of the very best bioenhancement supplements currently available.
Scientists believe that BioPerine enhances bioavailability by modifying the following three functions in the body:
P-glycoprotein present in the cell membrane controls the absorption and removal of foreign substances in the cell. It’s mostly found in the intestinal epithelium, liver cells, and kidneys. Research shows that piperine regulates the concentration of P-glycoprotein and CYP3A4. Glucuronidation is involved in the metabolism of androgens, estrogens, drugs, and more. Piperine influences the elimination of substances from the body by regulating Glucuronidation activity.
The role of thermogenesis in weight management is well known. Studies have found the process to be also associated with the absorption and utilization of the food and nutrients that are consumed. Research shows piperine stimulates thermogenesis by persuading the release of thermogenic hormones and catecholamines.
In 2010, the Journal of Ayurveda and Integrative Medicine published an article that states piperine has the ability to increase the absorption of Beta-carotene, CoQ10, Curcumin, Selenium, Resveratrol, Iron, Vitamin A, B6, and C. According to the article, the use of piperine could greatly benefit those suffering from malnutrition and malabsorption of nutrients.
Piperine is also believed to enhance cognition and treat anxiety and depression. This was reported in an article published in 2008, in the journal Food and Chemical Toxicology. According to another study reported in Pharmacology, Biochemistry, and Behavior, the main component in black pepper influenced the synthesis of dopamine and serotonin – two neurotransmitters closely associated with mood, stress, anxiety, and depression.
Involvement of Metabolism-permeability in Enhancing the Oral Bioavailability of Curcumin in Excipient-free Solid Dispersions Co-formed with Piperine
Guarana Powder - 270 mg
The prized fruit of the climbing plant Guarana is mainly found in the Amazon Basin. For centuries the Amazonian tribes have been using the Guarana extract for therapeutic purposes.
Even today, in many parts of the Amazon, Guarana seed syrup and paste are made into a drink and consumed as a health tonic. Guarana extract is known to aid weight loss, reduce fatigue and promote alertness, and fight eye-related disorders.
Guarana Benefits: The coffee seed-sized fruit contains an impressive array of antioxidants and stimulants. The antioxidants in Guarana include catechins, saponins, and tannins. Much of Guarana’s focus boosting and alertness promoting functions are because of stimulants such as caffeine, theobromine, and theophylline.
The stimulant caffeine fights fatigue and heightens alertness by attaching itself to the adenosine receptors. These receptors are responsible for relaxing the body and mind. Caffeine temporarily deactivates the receptors to boost alertness.
Caffeine is normally associated with sudden jolts of alertness – followed by a crash – yet Guarana provides a much smoother increase in mental alertness without the crash.
According to one study, a reduction in mental fatigue and improvement in cognitive performance was noticed in the volunteer group that took vitamin supplements with Guarana in it.
Multiple studies have established the cognition-enhancing properties of Guarana. In a study, the participants were divided into three groups, each receiving caffeine, guarana, or placebo tablets. After a series of tests, the researchers found the guarana group showed improvement in decision-making performance. In another study, people who took guarana completed the tests faster than the ginseng group. The results of animal studies show guarana displays acetylcholinesterase activity to reduce memory impairment.
The antioxidants in guarana help combat age-related eye disorders such as glaucoma, cataracts, and macular degeneration by reducing oxidative stress. According to a study, compared to a placebo, guarana worked better at preventing DNA damage that could have led to eye cell death.
Other health benefits of guarana aside from those to cognitive function include aiding weight loss, providing pain relief, improving heart health, and treating constipation and chronic diarrhea.
Mean Accuracy Score on a Memory Task Following Consumption of a Multi-vitamin with Guarana or Placebo Prior to the Test
Huperzine A - 150 mcg
Huperzine A – a natural water-soluble alkaloid derived from Chinese club moss Huperzia serrata. Hailed by many researchers for its action against neurodegenerative disorders, Huperzine A is fast becoming quite popular among the students for its benefits to memory and learning. Huperzine A is a quick acting nootropic, reaching its peak concentration within an hour of consumption. It’s also known for its high bioavailability and long half-life of 10 hours.
Huperzine A Benefits: The supplement’s ability to inhibit the functions of acetylcholinesterase and promoting transmission of nerve impulses is responsible for improving memory and learning. The enzyme acetylcholinesterase is responsible for degrading and depleting the levels of acetylcholine. By acting against acetylcholinesterase, Huperzine A ensures there is enough of the neurotransmitter in the brain to boost memory formation, storage, and recall.
Huperzine A’s role as a neuroprotectant has been proved and established by numerous scientific trials and studies. So much so, the nootropic is now an integral part of any adjunct therapy recommended for the treatment of Alzheimer’s and other neurodegenerative disorders.
The nootropic Huperzine A targets glutamate toxicity, which is one of the contributing factors of dementia. Excess of the excitatory neurotransmitter glutamate can cause age-related neurological disorders. Huperzine A can prevent cognitive decline by regulating the neurotransmitter level by blocking certain types of glutamate receptors.
Comparison of Factors of Wechsler Memory Scale between Two Groups (Before & After Trial)
Mucuna pruriens Extract - 375 mg
Extracted from the velvet bean, the nootropic Mucuna pruriens is the plant version of the amino acid Levodopa (L-Dopa). The amino acid is the precursor to three vital neurotransmitters – norepinephrine, dopamine, and epinephrine. Mucuna pruriens is mainly used to treat infertility, depression, and symptoms of Parkinson’s disease.
Mucuna pruriens is fast becoming the preferred source of L-Dopa. Two simple reasons for its wide acceptance: (a) the natural nootropic is made up of compounds that are found in the human body; and, (b) Mucuna pruriens is well tolerated by most users.
Mucuna pruriens Benefits: The three neurotransmitters – norepinephrine, dopamine, and epinephrine – are essential for positive mood, learning, memory, and other vital cognitive abilities. The shortage of any of the three brain chemicals is known to affect mood and cognition and in the long-term cause Parkinson’s or other neurodegenerative disorders. Most dopamine supplements are not effective because the neurotransmitter dopamine cannot cross the blood-brain barrier easily.
Studies show the high-level of L-Dopa in Mucuna pruriens converts to dopamine, which is further synthesized into norepinephrine and epinephrine. Compared to synthetic L-Dopa supplements, Mucuna pruriens cruises through the blood-brain barrier with ease. In addition, the Ayurvedic nootropic boasts of powerful antioxidants that fight oxidative stress and prevent cell damage.
In a study that involved 60 men suffering from infertility due to stress. The treatment group received a daily dose of 5grams of the supplement for 90 days. The test results at the end of the treatment showed increased sperm count, improved semen quality, and a considerable decrease in stress levels.
Scientists agree that L-Dopa is the best medicine available for treating Parkinson’s. Several researchers have started studying Mucuna pruriens as a natural source of Levodopa. Two recent randomized double-blind crossover trials have shown that Mucuna pruriens is a safe alternative to synthetic L-Dopa. In both studies, the use of Mucuna pruriens improved motor functions and the learning ability of the patients.
Mucuna pruriens also helps treat depression and supports optimal physical and mental performance in a stressful environment. In a study, lab mice fed with Mucuna pruriens seed extract were made to undergo Forced Swimming Test and Tail Suspension Test. The results proved that the Mucuna pruriens mice were able to handle stress better than the untreated group.
Comparative Evaluation of the Sexual Functions of Some Aphrodisiac Herbal Extracts in Male Rats - The Effect of Extracts on Sperm Count
Noopept - 37.5 mg
Noopept is a fast-acting cognitive enhancer with a strong neuroprotective effect. Noopept’s MOA is similar to piracetam, but in truth, noopept is far better and more powerful than the racetam. Noopept’s speed of action, strength, and safety, makes it the go-to synthetic nootropic.
The nootropic doesn’t take long to reach peak concentration; upon ingestion, noopept is processed in the liver and finds its way to the digestive system in no time. It effortlessly crosses the blood-brain barrier and in 20-30 minutes takes full effect.
Noopept Benefits: Noopept enhances cognition and learning by influencing the neurotransmitter acetylcholine. The actions of the synthetic nootropic don’t increase acetylcholine level, but it makes the neurons more sensitive to the brain chemical. Noopept further supports better memory and cognition by increasing two neurotrophin proteins – NGF and BDNF.
The strong anti-inflammatory and antioxidant properties of noopept help delay or even prevent the onset of age-related cognitive decline. Studies on rats have revealed that the supplement has the potency to treat severe symptoms of Alzheimer’s such as amnesia.
In addition, studies have also shown that noopept prevents neuronal damage by regulating the neurotransmitter glutamate and preventing glutamate toxicity. The nootropic maintains neurotransmitter balance by modulating the activity of NDMA and AMPA. By eliminating excess glutamate, the supplement aids long-term memory formation, increases neuroplasticity, and promotes cerebral blood circulation.
Effects of Noopept on NGF and BDNF (neurotrophin proteins) in Cerebral Cortex
Phosphatidylserine - 150 mg
Phosphatidylserine is actually fat that’s found in every cell in the body; nearly half of which is present in the brain. Presence of Phosphatidylserine (PS) is indispensable as it allows the efficient transfer of glucose, oxygen, nutrients, and enzymes, in and out of the cell. The fatty acid is also involved in neurogenesis and transmission of the signals within the brain cells and across the synapses. This phospholipid helps the cells produce more mitochondria and Nerve Growth Factor (NGF).
Phosphatidylserine Benefits: The most notable benefit of PS is to support memory formation by continuously increasing synaptic strength – a process known as Long-term Potentiation (LTP). Regular supplementation is also known to improve focus, concentration, and increase in mental energy.
Studies show PS’ abilities to stimulate neurotransmitter production, promote neurogenesis, improve neural communication, and boost neuronal health helps slow down age-related cognitive decline and prevent Alzheimer’s, Parkinson’s, and other dementia disorders.
PS is used with DHA fatty acid to treat ADHD/ADD and bipolar disorders. Studies show that PS increases dopamine production, and by doing so the nootropic alleviates stress, reduces anxiety, improves mood, and increases the overall feeling of well-being.
One of the many benefits of PS, not particularly related to cognition, is a clear boost to athletic performance and exercise capacity. The supplement cuts down the release of cortisol, which is triggered by an intense workout. Phosphatidylserine also decreases muscle soreness and muscle damage and helps users train harder and longer.
Shilajit® Powder - 187.5 mg
Found in rocks in the Himalayas and other mountain ranges, Shilajit is a sticky substance formed by the breaking down of mineral and plant material. Shilajit is mentioned in several Ayurvedic texts and has been part of the traditional medicine for thousands of years. The naturally-occurring substance is fast becoming popular due to its many positive effects on cognition and overall health.
Shilajit Benefits: The findings of several studies on this subject seem to suggest Shilajit supplementation can improve the symptoms of age-related neurodegenerative disorders such as Alzheimer’s. Much of its anti-aging activities are due to the active components – Fulvic and Humic Acid.
The Humic Acid is known to strengthen the immune system, whereas, the Fulvic Acid protects the brain by blocking the buildup of Tau protein. Our body requires tau for various chemical functions, but over-accumulation of the protein in the central nervous system (CNS) can lead to cell damage and cell death. The anti-inflammatory and antioxidant properties of the Fulvic Acid act against tau buildup.
In India, practitioners of traditional medicine recommend Shilajit to fight fatigue and improve sex life. Several studies have found evidence to support both these claims.
For the people suffering from Chronic Fatigue Syndrome even the day to day activities may appear as herculean tasks. Scientists blame mitochondrial dysfunction for chronic fatigue. In an animal study, Shilajit was administered to rats with lab-induced CFS. After the treatment period of 21 days, the researchers found a reduction in the effects of chronic fatigue syndrome. Scientists believe that Shilajit fights fatigue and boosts energy levels by improving cell function.
The male sex hormone testosterone is responsible for several functions in the body. Low testosterone levels can affect sex life by decreasing libido. The deficiency of the male hormone can also increase body fat, cause fatigue, reduce muscle mass, and lead to hair loss.
In a study, volunteers were divided into the supplement and placebo group. All the participants were between 45 to 55 years of age. The supplement group received 250mg of Shilajit, twice a day. The result after 3 months of treatment showed improvement in testosterone levels in the supplement group.
The Effects of Shilajit Supplementation on Fatigue-induced decrease in Muscle Strength and Serum Hydroxyproline Levels
Taurine - 150 mg
Unlike other amino acids, Taurine isn’t used by the body to produce protein. This conditionally essential amino acid is concentrated in muscles, heart, eyes, and brain.
Hailed by some as a ‘wonder molecule’, Taurine is used in energy drinks and also as a supplement. It’s taken for its many health benefits, such as improved cognitive ability, boost physical performance, improved immunity, manage diabetes, and support heart and kidney health.
Taurine Benefits: Taurine is known to improve physical performance. In animals, researchers found the amino acid boosts the ability of muscle fibers to contract, which leads to increased force production. Also, the supplement encourages the muscles to work harder and prevents muscle damage.
Taurine is taken by bodybuilders and athletes to train harder, reduce fatigue, and improve endurance. Research shows that the amino acid fights fatigue by flushing out toxins and waste material that cause muscle burn and fatigue. The antioxidants in L-Taurine support athletic performance by reducing oxidative stress and cell damage.
Some dietitians suggest taking Taurine to promote weight loss. Studies show Taurine encourages the body to use fat, instead of carbohydrates, as the primary source of energy. The supplement is also recommended to augment the effects of the Ketogenic Diet.
The naturally occurring amino acid Taurine is known to have neuroprotective properties. It also believed to influence neurotransmitters and various receptors in the brain. In a study, Taurine given to mice with a rare neurodevelopmental disorder called Angelman Syndrome showed improvement in physical performance and learning ability. Some studies also suggest a combined dose of Taurine and Caffeine displayed significant improvement in mental performance.
Taurine is referred to as a ‘wonder molecule’ by some scientists due to its ability to improve life expectancy. Taurine deficiency is liked to various ailments including cancer, diabetes, kidney problems, and cardiovascular diseases. Supplementation of the amino acid increases longevity by fighting oxidative stress, preventing cell damage, controlling blood glucose level, managing blood pressure, and reducing bad cholesterol. Other potential health benefits of Taurine include reducing seizures and improving mood, hearing, and eyesight.
Taurine Administration Recovers Motor and Learning Deficits in an Angelman Syndrome Mouse Model
Uridine - 150 mg
Uridine is one of the five naturally occurring nucleotides that form a nucleic acid. Being part of RNA, it plays a crucial role in carrying messages to various cells in the body. Dietary uridine is known to offer many cognitive benefits, but a large chunk of uridine sourced from food gets digested, thus requiring supplementation.
Uridine supplements are highly bioavailable; the nootropic easily crosses the blood-brain barrier and converts to CDP Choline, which is needed for the synthesis of Phosphatidylcholine. The nootropic uridine is needed for the formation and repair of cell membranes. It’s also known to promote synaptogenesis and the neuronal process.
Part of PS, not used by the cell membranes, is used in the production of choline, which is needed for making acetylcholine. Uridine also influences the synthesis of other neurotransmitters, namely, the pleasure and reward chemical dopamine.
Uridine Benefits: The supplement’s ability to boost neurotransmitters, improve the development of cell membranes in the brain, and promote synapses formation directly benefits cognitive faculties such as memory and learning. Animal studies show that combined use of uridine and DHA can increase the levels of key cognitive compounds and improve performance in memory and learning tests.
Uridine’s action on dopamine influences mood and behavior. Studies show the nootropic to be very effective in treating depression and bipolar disorder in adolescents and adults.
In healthy subjects, uridine along with choline and DHA has the ability to improve cognition. Scientists believe that these three compounds can be effectively used to prevent cognitive decline and treat Alzheimer’s and other neurodegenerative disorders in elderly people.
Effects of Uridine and DHA on Phosphatide Levels in Whole-brain Samples (Associated with Learning and Memory)
Vitamin B6 (Pyridoxine HCI) - 36 mg
B6 (Pyridoxine HCI) is a water-soluble vitamin that acts as a cofactor to support enzymatic reactions. More than a hundred chemical reactions, most of them related to protein metabolism are dependent on the presence of Vitamin B6.
One of the many roles of Vitamin B6 is to assist in the production of neurotransmitters, more particularly those associated with sleep, concentration, and mood, namely, melatonin, serotonin, dopamine, and norepinephrine.
Additionally, Pyridoxine HCI or Vitamin B6 is also required for the normal functioning of the brain cells. It supports the development of the myelin sheath, which is a protective plasma membrane that drapes around the nerve fiber (axon).
Along with its fellow members (B9 and B12) of the B-Complex group, Vitamin B6 regulates homocysteine levels in the blood. Elevated levels of this nonprotein amino acid can affect the blood vessels, lead to depression and dementia, and increase the risk of cardiovascular diseases, stroke, and various other diseases. Low levels of Vitamin B6 and iron is also linked to a panic attack and a hyperventilation attack.
Vitamin B6 Benefits: The nootropic benefits of Pyridoxine HCI are primarily due to the vitamin’s ability to regulate homocysteine levels. Research shows that increased levels of B6 results in lowering of homocysteine, which is responsible for neuron damage and reduced cognitive function. Some studies show an inverse relationship between dopamine and Vitamin B6, leading to the theory that taking a B6 supplement can alleviate depression. Vitamin B6 also affects mood, sleep, dreams, REM cycle, alertness, memory, and cognition by aiding the synthesis of various neurotransmitters.
Vitamin B12 (Methylcobalamin) - 900 mcg
Cobalamin or Vitamin B12 is the second vitamin that’s part of the NITROvit brain enhancement stack. Supplementation of B12 is important because the body isn’t capable of producing cobalt endogenously, but it can store B12 in large amounts. Similar to B6 and B9, vitamin B12 has its fingers in many pies (i.e.) it’s a cofactor in hundreds of enzymatic reactions. Cobalamin exists in many forms, but NITROvit uses Methylcobalamin because it’s the easiest for the body to absorb.
Vitamin B12 Benefits: Vitamin B12 acts as a cofactor for a number of enzymes; it assists L-methylmalonyl-CoA mutase in protein and fat metabolism, methionine synthase in converting homocysteine to methionine, and also helps in the formation of red blood cells.
Vitamin B12 has a vital role to play in treating symptoms of depression. It helps regulate mood by aiding the release of serotonin. Research also links B12 deficiency to memory loss and brain atrophy. Experts believe that supplementation can improve memory even in the absence of B12 deficiency.
The methyl group donated by B12 is instrumental in the synthesis of neurotransmitters and hundreds of hormones. Vitamin B12 has dozens of scientifically validated benefits; the list includes a surge in energy level, decrease in the risk of age-related macular degeneration, diabetic neuropathy, atherosclerosis, and Alzheimer’s disease.
Role of Vitamin B12 in Treating Major Depressive Disorder